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fentanyl transdermal and diazepam the two boost sedation. Avoid or Use Alternate Drug. Limit use to sufferers for whom choice cure selections are insufficientObserve Carefully (1)crofelemer improves levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the opportunity to inhibit CYP3A4 at c